17 April 2020
The Animal Pharm ‘Disruptors and Innovators’ report has named Biotangents as a top 20 company for 2020.
Animal Pharm and Stonehaven Consulting partnered to provide an overview of the growing volume of innovation coming from animal health start-ups – a part of the sector that is increasing at a rapid rate.
The companies covered hail from across the globe and are in a multitude of products areas across all species. These include organisations working on diagnostics, vaccines, feed additives, companion animal drugs, digital technologies and more next-generation product candidates. Biotangents were selected due to their proprietary diagnostic technology, Moduleic Sensing™, and for bringing lab-quality testing capabilities to the point of care market.
Innovative chemistry
Moduleic Sensing™ reports the presence of DNA or RNA sequences specific to a disease, pathogen or antibiotic resistance gene of concern. It is an isothermal amplification system, meaning that, unlike competing PCR-based approaches, it requires only one operating temperature and removes the need for rapid temperature cycling equipment. We achieve this through our unique modular design. The modular nature makes it rapidly adaptable to new targets and straightforward to integrate into multiple results reporting methods, including lateral flow, colour-change, fluorescence detection and electrochemical sensing
AI-enhanced design
Our proprietary machine-learning-based bioinformatics workflows enable diagnostic design capabilities beyond what human-guided design can deliver alone. These algorithms identify targets, validate genetic markers of disease, and design the molecular probes that recognise those markers. This supports the rapid generation of new diagnostic tests and aids us in identifying new targets, validating genetic markers of disease, and designing the molecular probes that recognise those markers.
1. Detection module defines the nucleic acid sequence to be detected (determined by bioinformatic analysis)
2. Amplification module sets the sensitivity through generation of an interim genetic signal
3. Reporting module controls how the result is observed by the operator (e.g. as a visual colour change)